Recent Publications

Complete List of Publications Can Be Found Here

  1. Cooper S.Y., Olszewski N.A., Tetteh-Quarshie S., Hill S.P., Ghodsi S., González-Castro A., Willis C.V., Henderson B.J. (2023) The impact of high or low doses of nicotine in a mouse model of vapor self-administration. Nicotine & Tobacco Research, ntad136, https://doi.org/10.1093/ntr/ntad136

  2. Cooper, S.Y.; Willis, C.V.; Richardson, M.R.; Wright, S.K.; Elmore, M.B.; Mitchell, Z.B.; and Henderson, B.J. (2023) Green apple e-cigarette flavorants alter neurobiology in a sex-dependent manner to promote vaping-related behaviors. J Neurosci. Featured Article. DOI: https://doi.org/10.1523/JNEUROSCI.0755-22.2022

  3. Henderson, B.J. and Cooper, S.Y. (2021) Nicotine formulations impact reinforcement-related behaviors in a mouse model of vapor self-administration. Drug and Alcohol Dependence. DOI: https://doi.org/10.1016/j.drugalcdep.2021.108732

  4. Akers, A.T.; Baumgard, Z.J.; Avelar, A.J.; Cooper, S.Y.; Lester, H.A.; and Henderson, B.J. (2020) Upregulation of α4* and α4α6* nAChRs on VTA dopamine neurons is correlated with nicotine reward-related behavior. eNeuro. DOI: https://doi.org/10.1523/ENEURO.0189-20.2020

  5. Cooper, S.Y. and Henderson, B.J. (2020) The impact of electronic nicotine delivery system (ENDS) flavors on nicotinic acetylcholine receptors and nicotine addiction-related behaviors. Molecules. DOI: https://doi.org/10.3390/molecules25184223

  6. Cooper, S.Y.; Akers, A.T.; and Henderson, B.J. (2020) Flavors enhance vapor self-administration of nicotine in male mice. Nic Tob Res. DOI:  https://doi.org/10.1093/ntr/ntaa165

  7. Cooper, S.Y.; Akers, A.T.; and Henderson, B.J. (2020) Green apple e-cigarette flavorant farnesene triggers reward-related behavior by promoting high-sensitivity nAChRs in the ventral tegmental area. eNeuro. https://doi.org/10.1523/ENEURO.0172-20.2020

  8. Avelar, A.J.; Akers, A.T.; Baumgard, Z.J.; Cooper, S.Y.; Casinelli, G.P.; and Henderson, B.J. (2019) Why flavored tobacco products may be attractive: green apple tobacco flavor triggers reward-like behavior, upregulates nAChRs on VTA dopamine neurons, and alters VTA dopamine neuron function. Neuropharmacology, DOI: https://doi.org/10.1016/j.neuropharm.2019.107729 (LINK)

  9. Fu, X.; Moonschi, F.H.; Fox-Loe, A.M.; Snell, A.A.; Hopkins, D.M.; Avelar, A.J.; Henderson, B.J.; Pauly, J.R.; Richards, C.I. (2019) Brain region specific single-molecule fluorescence imaging. Anal Chem, DOI: 10.1021/acs.analchem.9b02133.

  10. Bavan, S.; Kim, C.H.; Henderson, B.J.; and Lester, H.A. (2018) Chronic menthol at mouse α3β4-containing nicotinic acetylcholine receptors. Mol Pharmacol. mol.118.114769; DOI: https://doi.org/10.1124/mol.118.114769

  11. Henderson, B.J.*; Grant, S.*; Wong, B.K.; Shahoei, R.; Huard, S.S.; Saladi, S.; Tajhorshid, E.; Dougherty, D.A.; and Lester, H.A. (2018) Menthol stereoisomers exhibit different effects on α4β2 nAChR upregulation and dopamine neuron spontaneous firing. eNeuro. DOI: https://doi.org/10.1523/ENEURO.0465-18.2018

  12. Wall, T.R.*; Henderson, B.J.*; Voren, G.; Wageman, C.R.; Deshpande, P.; Cohen, B.N.; Grady, S.R.; Marks, M.J.; Yohannes, D.; Bencherif, M.; Kenny, P.J.; and Lester, H.A. (2017) TC299423, a novel agonist for nicotinic acetylcholine receptors. Frontiers in Pharmacology. *, designates co-first authorship. DOI: 10.3389/fphar.2017.00641

  13. Henderson, B.J.; Wall, T.R.; Henley, B.M.; Kim, C.H.; McKinney, S.; and Lester, H.A. (2017) Menthol enhances nicotine reward-related behavior by potentiating nicotine-induced changes in nAChR function, nAChR upregulation, and DA neuron excitability. Neuropsychopharmacology. DOI: 10.1038/npp.2017.72

  14. Fox-Lee, A.M.; Henderson, B.J.; Richards, C.I. (2016) Utilizing pHluorin-tagged receptors to monitor subcellular localization and trafficking. J Vis Exp (121), e55466, DOI: 10.3791/55466

  15. Nichols, W.A.; Henderson, B.J.; Yu, C.Y.; Marotta, C.B.; Richards, C.I.; Dougherty, D.A.; Cohen, B.N.; and Lester, H.A. (2016) Suppression of low-sensitivity α4β2 nicotinic receptor expression by a mutation linked to autosomal dominant nocturnal frontal lobe epilepsy. PLoS ONE. 2016 Jun 23;11(6):e0158032. doi: 10.1371/journal.pone.0158032. eCollection 2016. PMID: 27336596

  16. Henderson, B.J.; Wall, T.; Henley, B.M.; Kim, C.H.; Nichols, W.A.; Xiao, C.; and Lester, H.A. (2016) Menthol alone upregulates midbrain nAChRs, alters nAChR subtype stoichiometry, alters dopamine neuron firing frequency, and prevents nicotine reward. J Neurosci. 36, 2957-2974. DOI: 10.1523/JNEUROSCI.4194-15.2016

  17. Srinivasan, R.; Henley, B.M.; Henderson, B.J.; Indersmitten, T.; Mckinney, S.; Deshpande, P.; Xiao, C.; and Lester, H.A. (2016) Smoking-relevant nicotine concentration inhibits the unfolded protein response in dopaminergic neurons. J Neurosci. 36, 69-75. DOI: 10.1523/JNEUROSCI.2126-15.2016

  18. Henderson, B.J. and Lester, H.A. (2015) Inside-out neuropharmacology of nicotinic drugs. Neuropharmacology. 96 Part B, 178-193. DOI:10.1016/j.neuropharm.2015.01.022.

  19. Xiao, C.; Miwa, J.M.; Henderson, B.J.; Wang, Y.; Deshpande, P.; McKinney, S.L.; Lester, H.A. (2015) Nicotinic receptor subtypes within selective circuits of the subthalamic nucleus. J Neurosci. 35, 3734-3746. DOI: 10.1523/JNEUROSCI.3528-14.2015. Featured Article

  20. Nichols, W.A.; Henderson, B.J.; Yu, C.Y.; Parker, R.L.; Richards, C.I.; Lester, H.A.; and Miwa, J.M. (2014) Lynx1 shifts α4β2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum. J Biol Chem. 289, 31423-31432. DOI:10.1074/jbc.M114.573667

  21. Srinivasan, R.; Henderson, B.J.; Lester, H.A.; and Richards, C.I. (2014) Pharmacological chaperoning of nAChRs: a new therapeutic target for Parkinson’s disease. Pharmacol Res. 83, 20-29. DOI: 10.1016/j.phrs.2014.02.005

  22. Henderson, B.J.; Srinivasan, R.; Nichols, W.N.; Dilworth, C.; Gutierrez, D.F.; McKinney, S.; Mackey, E.D.W.; Drenan, R.M.; Richards, C.I.; and Lester, H.A. (2014) Nicotine exploits a COPI-mediated process for chaperone-mediated upregulation of its receptors. J Gen Physiol. 143, 51-56. Cover Article (Link to Video Synopsis)

Press releases and commentaries

  1. Press Releases for our work on green apple vaping flavorant farnesene (published in eNeuro): https://eneuro.altmetric.com/details/87090581/news

  2. (Commentary) 2017. Lallai, V. and Fowler, C.D. More than just chillin’: interactive effects of menthol and nicotine in drug reward. Neuropsychopharmacology. DOI: 10.1038/npp.2017.107

  3. (Interview) 2017. Society for Research on Nicotine & Tobacco (SRNT) Scientist Spotlight: Dr. Brandon Henderson

  4. (Press Release) 2017. Speaking of Research. "Of Mice and Mint: Animal research uncovers an unknown role for menthol in tobacco addiction."

  5. (Press Release) 2014. New Scientist. Menthol increases nicotine addiction by tweaking brain.

  6. (Press Release) 2014. Rockefeller University Press. Nicotine exploits COPI to foster addiction.

  7. (Commentary) Anand, R. COPI polices nicotine-mediated up-regulation of nicotinic receptors. J Gen Physiol. 143, 49-50.

  8. (Press Talk) Henderson, B.J. and Lester H.A. Why smokers of menthol cigarettes may find it harder to quit: menthol’s interaction with certain brain receptors may potentiate the addiction to nicotine. Society for Neuroscience Press Conference 2014: Legal Drugs of Abuse. Washington D.C., November 2014.

Updated, February 2017